Advanced paternal age and de-novo complex chromosomal rearrangement in offspring.
نویسندگان
چکیده
We report one case of a de-novo complex chromosomal rearrangement (CCR), t(1;5;13)ins(14;13), in an abnormal 19-month-old boy. Clinical features associated were a mild facial dysmorphy and a psychomotor retardation. Parental ages were, respectively, 29 years for the mother and 60 years for the father. We point out the usefulness of fluorescence in-situ hybridization in elucidating CCRs, and discuss the possible correlation between the existence of a chromosomal aberration and advanced paternal age.
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ورودعنوان ژورنال:
- Human reproduction
دوره 13 7 شماره
صفحات -
تاریخ انتشار 1998